TMIC-56. TUMOR CELL ARCHITECTURAL HETEROGENEITY AND SPATIAL INTERACTIONS WITH THE TUMOR IMMUNE MICROENVIRONMENT IN GBM
نویسندگان
چکیده
Abstract INTRODUCTION Glioblastoma (GBM) contains cell populations with distinct metabolic requirements, fast-cycling cells harnessing aerobic glycolysis, and treatment-resistant slow-cycling (SCCs) preferentially engaging lipid metabolism. The interaction between immune tumor cells, how their heterogeneity shapes the landscape in GBM has yet to be understood. Objectives: primary objective of this project is spatially molecularly decode microenvironment a specific focus on unraveling links that underlie SCCs compartment. METHODS Multiple murine glioma lines coupled geospatial profiling were used establish communications, while various genetic pharmacological approaches applied assess effect disrupting interplay system. RESULTS We determined exhibit dependencies, involving preferential metabolism supported by enhanced fatty acid uptake. also found distribution progression regulated interactions suppressive which turn work against rejection inhibiting T anti-tumor activity. shaped marked features enhancing exchange capacities are exploited support survival functions. Importantly, sensitized tumors chemotherapy. CONCLUSION Our results reveal tumor-associated within play critical role development drug resistant tumors. This study delineates these communications assesses potential therapeutic treat GBM. insights generated from uncover fundamental principles emerging connections microenvironment, metabolism, immunity, associated vulnerabilities.
منابع مشابه
Non-linear tumor-immune interactions arising from spatial metabolic heterogeneity
A hybrid multiscale mathematical model of tumor growth is used to investigate how tumoral and microenvironmental heterogeneity affect the response of the immune system. The model includes vascular dynamics and evolution of metabolic tumor phenotypes. Cytotoxic T cells are simulated, and their effect on tumor growth is shown to be dependent on the structure of the microenvironment and the distri...
متن کاملImmune Cell Population in Ovarian Tumor Microenvironment
Ovarian cancer, the third most common with highest mortality rates gynecological malignancy among women in China, is characterized by a unique tumor immune microenvironment. Immune-cell population infiltrated into the tumor tissue among patients with ovarian cancer are associated positively or negatively with antitumor activity. The imbalance between immune activation and immune suppression can...
متن کاملSTAT3 as a Key Factor in Tumor Microenvironment and Cancer Stem Cell
Background Recent studies revealed that tumor-associated macrophages (TAMs) play a decisive role in the regulation of tumor progression by manipulating tumor oncogenesis, angiogenesis and immune functions within tumor microenvironments. Signal transducer and activator of transcription 3 (STAT3), which is a point of convergence for numerous oncogenic signalling pathways, is constitutively activ...
متن کاملMonitoring immune responses in the tumor microenvironment.
Immune monitoring in the tumor microenvironment allows for important insights into immune mechanisms of response and resistance to various cancer treatments; however clinical challenges exist using current strategies. Significant questions remain regarding monitoring of archival versus fresh tissue, assessment of static versus dynamic markers, evaluation of limited tissue samples, and the trans...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuro-oncology
سال: 2022
ISSN: ['1523-5866', '1522-8517']
DOI: https://doi.org/10.1093/neuonc/noac209.1100